Evaluating Efficacy and Safety: Ketamine Versus Midazolam for Pediatric Pre-Medication in Anesthesia

EasyChair Preprint 14960

Abstract

This study evaluates the efficacy and safety of ketamine compared to midazolam for pediatric pre-medication in anesthesia. A randomized controlled trial was conducted involving 120 children aged 2 to 12 years, scheduled for elective surgery. Participants received either ketamine (1 mg/kg) or midazolam (0.5 mg/kg) prior to anesthesia induction. The primary outcome measured was the quality of sedation assessed using the Ramsay Sedation Scale, while secondary outcomes included incidence of adverse effects and time to onset of sedation. Results indicated that ketamine provided superior sedation quality compared to midazolam (p < 0.01), with a quicker onset time. Adverse effects were minimal for both agents, though ketamine was associated with a higher incidence of transient dissociative symptoms. The findings suggest that ketamine may be a more effective option for pediatric pre-medication in anesthesia, though careful monitoring for dissociative effects is warranted. These results support further investigation into optimized sedation protocols for pediatric patients undergoing surgery.

Keyphrases: Patients, Pediatric, Protocols, Surgery., investigation, optimized, sedation, undergoing

@booklet{EasyChair:14960,
  author    = {Adeyeye Barnabas},
  title     = {Evaluating Efficacy and Safety: Ketamine Versus Midazolam for Pediatric Pre-Medication in Anesthesia},
  howpublished = {EasyChair Preprint 14960},
  year      = {EasyChair, 2024}}