Regulation of Signaling Pathways Involved in Liver Protection

EasyChair Preprint 14414

Abstract

The liver plays a crucial role in maintaining overall bodily homeostasis, and its proper function is essential for survival. Consequently, the regulation of signaling pathways that promote liver protection and regeneration is of great importance. This review outlines several key signaling cascades that are central to the liver's response to injury and stress.

The transforming growth factor-beta (TGF-β) signaling pathway is a major player in both liver injury and regeneration. TGF-β signaling can induce both pro-apoptotic and pro-proliferative effects in hepatocytes, depending on the cellular context. The regulation of TGF-β signaling involves Smad-dependent and Smad-independent mechanisms, and modulation of this pathway is a potential therapeutic target.

Keyphrases: Canonical pathway, Inflammation, NF-κB, Non-canonical pathway, liver injury

@booklet{EasyChair:14414,
  author    = {Elizabeth Henry},
  title     = {Regulation of Signaling Pathways Involved in Liver Protection},
  howpublished = {EasyChair Preprint 14414},
  year      = {EasyChair, 2024}}